Selling a house that needs work takes time and money to make it worth it. Selling your home as-is means that the property will be sold as it currently sits, with all of the flaws it has developed over time. The seller will not invest in home improvements, and any requests by potential buyers for repairs on the property will be outright denied.
In most states, selling your house as-is means that any home buyer will have to sign an agreement that requires the seller to reveal the full extent of the status of the home.
Choosing one route or another depends on your situation and how you feel about the future, but if you are looking to get out and sell quickly without having to invest in repairs, it would be smart to consider selling your home as-is.